incorporation of honey and Nepeta dschuparensis together into chitosan/poly(vinyl

alcohol) electrospun nanofibre triggers the healing rate of the wounds in animal

model. In in vivo experiment, the treatment of a second-degree burn injury of rats

has been carried out with developed dressing material, and the healing efficacy is

determined with respect to 1% silver sulfadiazine treated group (Naeimi et al. 2020).

A faster wound contraction is observed with the developed dressing material after

21 days of treatment which is further supported by the histopathological investiga-

tion. Minimal inflammation, higher angiogenesis and increased collagen deposition

are observed with the developed dressing material after 21 days of treatment, while

slow wound contraction, higher necrosis and less collagen deposition are

Fig. 30.2 In vivo study with different wound dressing materials: (a) the circular wounds on rats are

treated with vitexin-loaded chitosan hydrogel, madecassol and pure chitosan hydrogel, and the

wound contraction is observed with time; (b) the histopathological study exhibits superior healing

properties of herbal drug-loaded chitosan hydrogel in terms of re-epithelialization and vasculariza-

tion as compared to pure chitosan and madecassol group; (c) the excisional wounds on albino rats

are treated with herbal drug ‘panchavalkala’-loaded solution, PLA film and electrospun scaffold.

The wound contraction is observed with time and compared with control; and (d) the histopath-

ological studies indicates faster healing with drug-loaded scaffold in terms of greater angiogenesis,

construction of granulation tissues and less inflammation

30

Polymeric Vehicles for Controlled Delivery of Ayurvedic Drugs for Wound. . .

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